Eligible ages: 18 to 100

Inclusion criteria: 
1) Male of female ≥ 18 years old
2) Diagnosed with Primary Aldosteronism
3) Are willing to stop some medications that treat blood pressure, as directed by the study doctor (Mineralcorticoid Receptor Antagonists and potassium-sparing diuretics)
4) Must have healthy kidney functions as indicated by eGFR > 45 at screening visit
5) Specific serum potassium levels at screening
6) Females of child-bearing-potential must be willing to use contraception up to one month after the study medication has been stopped

Exclusion criteria:
1) Excessively high or low blood pressure
2) Surgical treatment for kidney issues must be evaluated
3) Other heart, liver, endocrine or secondary causes of hypertension considered relevant in the protocol or by the study doctor
4) Current medications will be reviewed and assessed by the study team and may be exclusionary or require adjustment

For more information, contact study coordinator Michelle Smith
mahunter@ucalgary.ca
403-955-8117

We are looking for people living with type 1 diabetes who have ongoing low blood sugar, particularly at night, but have otherwise stable diabetes management. Participants should not have frequent severe hypoglycemia or recent visits to the hospital because of diabetes problems.

This study will explore if a new medication, only available in a research study, can reduce nighttime low blood sugar events.

One of three drug doses will be compared to a placebo for each research participant to see if blood sugars are better managed overnight and throughout the day.

Total time in study is approximately 18 weeks (4.5 months). Study visits are conducted in the mornings at the Clinical Trials Unit at Richmond Road Diagnostic and Treatment Centre.

Eligible ages: 18 to 75

Inclusion criteria:

1) Adult living with Type 1 Diabetes for at least 5 years
2) Nighttime low blood sugar is a recurring issue (<3.0mmol/L bimonthly, or time-below-range ≥1% in an ambulatory glucose profile average over 28 days)
3) Stable diabetes management routine (diet and exercise, medications)
4) Not planning a pregnancy and agree to use highly effective birth control
5) Other clinically relevant markers of health must be reviewed by the investigator

Exclusion criteria:

1) Hospitalization for Diabetic Ketoacidosis in the last 6 months will be reviewed
2) Severe hypoglycemia requiring assistance in the last 3 months will be reviewed

For more information, contact study coordinator Michelle Smith

mahunter@ucalgary.ca

403-955-8117