Publications

Journal Articles

Shearer J, Scantlebury MH, Rho JM, Tompkins TA, Mu C. Role of Acid-Sensing Ion Channels 1a in the Regulation of Obesity and the Gut Microbiota. Obesity 34(2), 372-381.

Preprints

Wang W, Fortuna R, Mayengbam S, Seerattan RA, Mu C, Rios JL, et al. Microbial mechanisms underlying prebiotic-linked improvements in physical function and metabolism in knee osteoarthritis and obesity. medRxiv.

Journal Articles

Mu C, Rho JM, Shearer J. The interplay between the gut and ketogenic diets in health and disease. Advanced Science12(36), e04249.

Mu C, Shen J, Wang H, Yu K, Su Y, Zhu W. Casein hydrolysate enhances upper gastrointestinal chemosensing and gastric acid secretion in pigs. Journal of Agricultural and Food Chemistry 73(13), 7857-7866.

Shah S, Mu C, Shen-Tu G, Schlicht K, Forkert ND, Laudes M, Köfeler HC, et al. Altered tryptophan metabolism and gut immune crosstalk in hypertensive middle-aged women. American Journal of Physiology – Heart and Circulatory Physiology 329(5).

Shah S, Mu C, Shen-Tu G, Schlicht K, Rohmann N, Forkert N, Laudes M, Köfeler H, et al. Influence of dietary components on the gut microbiota of middle-aged adults: the gut-Mediterranean connection. BMC Microbiology 25(1), 573.

Scheidl TB, Wager JL, Shearer J, Thompson JA, Mu C. Cross talk between obesogenic diet and estrogen drives distinct microbiota profiles in ovariectomized mice. Physiological Genomics 57(12), 734-743.

Butowski CF, Dixit Y, Reis MM, Mu C. Metatranscriptomics for understanding the microbiome in food and nutrition science. Metabolites 15(3), 185.

Li X, Mu C, Wu H, Zoetendal EG, Huang R, Yu K, Zhu W. Superior ability of dietary fiber utilization in obese breed pigs linked to gut microbial hydrogenotrophy. ISME Communications 5(1), ycaf043.

Pi Y, Mu C, Gao K, Liu Z, Peng Y, Yu K, Su Y, Zhu W. Increasing carbohydrates or nitrogenous compounds by cecal infusion leads to an opposite influence on colonic microbiota and host metabolism in a pig model. Animal Nutrition.

Protocols

Ram TR, Mu C, Campbell JC, MacEachern SJ, Shearer J. Protocol for measuring mitochondrial respiratory capacity from buccal cell swabs. STAR Protocols 6(3).

Journal Articles

Wu H, Mu C, Xu L, Yu K, Shen L, Zhu W. Host-microbiota interaction in intestinal stem cell homeostasis. Gut Microbes16(1), 2353399.

Wu H, Mu C, Li X, Fan W, Shen L, Zhu W. Breed-driven microbiome heterogeneity regulates intestinal stem cell proliferation via Lactobacillus-Lactate-GPR81 signaling. Advanced Science 11(33), 2400058.

Mu C, Kesler M, Chen X, Shearer J, Teskey GC, Rho JM. Exogenous ketones exert antiseizure effects and modulate the gut microbiome and mycobiome in a clinically relevant murine model of epilepsy. Epilepsia 65(12), 3676-3688.

Shearer J, Shah S, Shen-Tu G, Schlicht K, Laudes M, Mu C. Microbial features linked to medication strategies in cardiometabolic disease management. ACS Pharmacology & Translational Science 7(4), 991-1001.

Shearer J, Shah S, MacInnis MJ, Shen-Tu G, Mu C. Dose-responsive effects of iron supplementation on the gut microbiota in middle-aged women. Nutrients 16(6), 786.

Li Y, Liu Y, Mu C, Zhang C, Yu M, Tian Z, Deng D, Ma X. Magnolol-driven microbiota modulation elicits changes in tryptophan metabolism resulting in reduced skatole formation in pigs. Journal of Hazardous Materials 467, 133423.

Xu L, Li X, Han S, Mu C, Zhu W. Galacto-oligosaccharides regulate intestinal mucosal sialylation to counteract antibiotic-induced mucin dysbiosis. Food & Function 15(24), 12016-12032.

Han YC, Laketic K, Hornaday KK, Slater DM, Mu C, Tough SC, Shearer J. Maternal acylcarnitine disruption as a potential predictor of preterm birth in Primigravida: a preliminary investigation. Nutrients 16(5), 595.

Protocols

Wang W, Choudhary A, Mu C, Scantlebury MH, Shearer J, Reimer RA. Protocol for nutritional intervention in neonatal rats using the "pup-in-a-cup" artificial rearing system. STAR Protocols 5(1).

Journal Articles

Shah S, Mu C, Moossavi S, Shen-Tu G, Schlicht K, Rohmann N, Geisler C, et al. Physical activity-induced alterations of the gut microbiota are BMI dependent. The FASEB Journal 37(4), e22882.

Shearer J, Scantlebury MH, Rho JM, Tompkins TA, Mu C. Intermittent vs continuous ketogenic diet: impact on seizures, gut microbiota, and mitochondrial metabolism. Epilepsia 64(8), e177-e183.

Liu Z, Mu C, Zhu W. Metagenomics-based inference of microbial metabolism towards neuroactive amino acids and the response to antibiotics in piglet colon. Amino Acids 55(10), 1333-1347.

Liu Z, Ling Y, Peng Y, Han S, Ren Y, Jing Y, Fan W, Su Y, Mu C, Zhu W. Regulation of serotonin production by specific microbes from piglet gut. Journal of Animal Science and Biotechnology 14(1), 111.

Cui L, Zeng H, Hou M, Li Z, Mu C, Zhu W, Hang S. Lactiplantibacillus plantarum L47 and inulin alleviate enterotoxigenic Escherichia coli induced ileal inflammation in piglets. Animal Nutrition 14, 370-382.

Protocols

Mu C, Shearer J. Protocol for measuring respiratory function of mitochondria in frozen colon tissue from rats. STAR Protocols 4(4).

Journal Articles

Jing Y, Mu C, Wang H, Shen J, Zoetendal EG, Zhu W. Amino acid utilization allows intestinal dominance of Lactobacillus amylovorus. The ISME Journal 16(11), 2491-2502.

Mu C, Choudhary A, Mayengbam S, Barrett KT, Rho JM, Shearer J, et al. Seizure modulation by the gut microbiota and tryptophan-kynurenine metabolism in an animal model of infantile spasms. EBioMedicine 76.

Mu C, Nikpoor N, Tompkins TA, Choudhary A, Wang M, Marks WN, et al. Targeted gut microbiota manipulation attenuates seizures in a model of infantile spasms syndrome. JCI Insight 7(12), e158521.

Mu C, Nikpoor N, Tompkins TA, Rho JM, Scantlebury MH, Shearer J. Probiotics counteract hepatic steatosis caused by ketogenic diet and upregulate AMPK signaling in a model of infantile epilepsy. EBioMedicine 76.

Mu C, Tompkins TA, Rho JM, Scantlebury MH, Shearer J. Gut-based manipulations spur hippocampal mitochondrial bioenergetics in a model of pediatric epilepsy. Biochimica et Biophysica Acta – Molecular Basis of Disease 1868(9), 166446.

Mu C, Pochakom A, Reimer RA, Choudhary A, Wang M, Rho JM, et al. Addition of prebiotics to the ketogenic diet improves metabolic profile but does not affect seizures in a rodent model of infantile spasms syndrome. Nutrients 14(11), 2210.

Pochakom A, Mu C, Rho JM, Tompkins TA, Mayengbam S, Shearer J. Selective probiotic treatment positively modulates the microbiota–gut–brain axis in the BTBR mouse model of autism. Brain Sciences 12(6), 781.

Zhang Y, Mu C, Liu S, Zhu W. Dietary citrus pectin drives more ileal microbial protein metabolism and stronger fecal carbohydrate fermentation over fructo-oligosaccharide in growing pigs. Animal Nutrition 11, 252-263.

Wang W, Mu C, Cho NA, Tuplin EWN, Lowry DE, Chleilat F, Sales KM, et al. Effect of supplementation with select human milk oligosaccharides on artificially reared newborn rats. British Journal of Nutrition 128(10), 1906-1916.

Li Z, Ding L, Mu C, Zhu W, Hang S. Duodenal infusion of soy protein hydrolysate activates cAMP signaling and hypothalamic neurotransmitter synthesis in pigs. Food & Function 13(23), 12067-12076.

Laketic K, Lalonde-Bester S, Smyth K, Slater DM, Tough SC, Ishida H, Mu C, et al. Maternal metabolites indicative of mental health status during pregnancy. Metabolites 13(1), 24.

Goudie L, Mancini NL, Shutt TE, Holloway GP, Mu C, Wang A, McKay DM, et al. Impact of experimental colitis on mitochondrial bioenergetics in intestinal epithelial cells. Scientific Reports 12(1), 7453.

Book Chapters

Mu C, Shearer J, Scantlebury MH, Marks WN. The Ketogenic Diet and the Gut Microbiome. Ketogenic Diet and Metabolic Therapies: Expanded Roles in Health and Disease. 2022.

Journal Articles

Choudhary A, Mu C, Barrett KT, Charkhand B, Williams-Dyjur C, et al. The link between brain acidosis, breathing and seizures: a novel mechanism of action for the ketogenic diet in a model of infantile spasms. Brain Communications 3(4), fcab189.

Wang H, Shen J, Mu C, Gao K, Pi Y, Zhu W. Low crude protein diets supplemented with casein hydrolysate enhance the intestinal barrier function and decrease the pro-inflammatory cytokine expression in the small intestine. Animal Nutrition7(3), 770-778.

Book Chapters

Mu C, Pi Y, Zhang C, Zhu W. Microbiomes in the intestine of developing pigs: implications for nutrition and health. Recent Advances in Animal Nutrition and Metabolism, 161-176.

Journal Articles

Gao K, Mu C, Farzi A, Zhu W. Tryptophan metabolism: a link between the gut microbiota and brain. Advances in Nutrition 11(3), 709-723.

Li Z, Mu C, Xu Y, Shen J, Zhu W. Changes in the solid-, liquid-, and epithelium-associated bacterial communities in the rumen of Hu lambs in response to dietary urea supplementation. Frontiers in Microbiology 11, 244.

Pi Y, Mu C, Gao K, Liu Z, Peng Y, Zhu W. Increasing the hindgut carbohydrate/protein ratio by cecal infusion of corn starch or casein hydrolysate drives gut microbiota-related bile acid metabolism to stimulate colonic barrier function. mSystems 5(3).

Shen J, Mu C, Wang H, Huang Z, Yu K, Zoetendal EG, Zhu W. Stimulation of gastric transit function driven by hydrolyzed casein increases small intestinal carbohydrate availability and its microbial metabolism. Molecular Nutrition & Food Research 64(21), 2000250.

Shah S, Brown PDS, Mayengbam S, Gänzle MG, Wang W, Mu C, et al. Metabolic and gut microbiota responses to sourdough pasta consumption in overweight and obese adults. Frontiers in Nutrition 7, 615003.

Zhang CJ, Yu M, Yang YX, Mu CL, Su Y, Zhu WY. Effect of early antibiotic intervention on specific bacterial communities and immune parameters in the small intestine of growing pigs fed different protein level diets. Animal14(10), 2042-2053.

Yu M, Mu C, Zhang C, Yang Y, Su Y, Zhu W. Long-term effect of early antibiotic exposure on amino acid profiles and gene expression of transporters and receptors in the small intestinal mucosa of growing pigs. Journal of the Science of Food and Agriculture 100(1), 235-244.